root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. Remenapp A, Coyle K, Orange T, et al. . For this reason, it's always best to tell a healthcare provider if you are taking any medications and/or supplements before starting a new supplement. Since the effects of grapefruit juice may last as long as 3 days, it should be avoided if you are taking atorvastatin (Lipitor), lovastatin (Mevacor, Altoprev) or simvastatin (Zocor). The body naturally produces thyroid hormones. View abstract. Some people may need to avoid taking Ashwagandha, however, including those who: At the end of the study, significant improvements in general memory and immediate memory were seen in the ashwagandha group. Synthroid is not known to interact with these supplements. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. Ghosal S, Lal J, Srivastava R, and et al. Next Steps to Take, Understanding Your Childs Life With ADHD. Is Fish Oil Dangerous With Antidepressants? Adv Exp Med Biol. 2011;68(1):3-8. https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. 2019;98(37):e17186. However, some other statins do not seem to be affected by grapefruit juice, including pravastatin (Pravachol), fluvastatin (Lescol) and rosuvastatin (Crestor). Devi, P. U., Sharada, A. C., and Solomon, F. E. In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma. J Ethnopharmacol. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25. National Institutes of Health Office of Dietary Supplements. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. According to their lab study, withanone may interfere with DNA, leading to liver damage. View abstract. View abstract. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. Singh P, Salman KA, Shameem M, Warsi MS. Withania somnifera (L.) Dunal as add-on therapy for COPD patients: a randomized, placebo-controlled, double-blind study. Although ashwagandha is mainly considered safe, side effects may be possible. Most reported drug interactions are based on the potential additive effectswhen combined with certain drugs (e.g. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. One systematic review found just five human trials that studied ashwagandha as an anxiety treatment. This product may interfere with some lab tests. Some but not all ashwagandha supplements are organic. It may cause you to become sleepy or drowsy. Curr Clin Pharmacol. Ashwagandha may be able to help with insomnia. 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. You can mix other nonessential amino acids and antidepressants without any issues. Bull Natl Res Cent. 2021;51(4):363-365. Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Withania somnifera, also commonly as ashwagandha or winter cherry, is a shrub native to parts of Asia and Africa. 2021;270:113766. View abstract. Some of these interactions can be life-threatening. However, there is concern that herbs like ashwagandha may have interactions that have . Medicine (Baltimore). ; Vomiting and nausea. A few commonly prescribed benzodiazepines are: Alprazolam (Xanax) Clonazepam (Klonopin) Diazepam (Valium) Lorazepam (Ativan) Staff. J Clin Psychiatry. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. 2019;11(12):e6466. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! J Ethnopharmacol 1999;67:27-35. Be sure to confirm new supplements fit your dietary needs or preferences. J Altern Complement Med. When people can't obtain all of the nutrients the Food and Drug Administration recommends, they typically look into taking supplements. Some don't work well with prescription medicines. As a general rule of thumb, never exceed the recommended dose of ashwagandha. doi:10.1097/MD.0000000000017186, Pratte MA, Nanavati KB, Young V, Morley CP. There are a variety of essential vitamins and minerals you should consume on a daily basis. 2021 Nov 30;2021:8254344. For example, it may increase the sedative effect of medications that treat anxiety and insomnia. Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial. View abstract. In rare cases, ashwagandha may cause liver damage. What about black My Dr. put me on 500mg of cephalexin 3 times a day and 150mg of fluconazole. Ashwagandha might lower blood sugar levels. Ashwagandha interferes with immunoassay measurements of digoxin, a medication primarily used for treating congestive heart failure and abnormal heart rhythms. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. View abstract. From the study results, researchers concluded that ashwagandha improved memory and focus. Arch Pathol Lab Med 2007;131:1298-303. Ashwagandha may interact with certain drugs by enhancing or negating their actions. Created for people with ongoing healthcare needs but benefits everyone. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. With such a long list of claims, it's important to look closely at the research. Ashwagandha interacts with several types of prescription medicine, so consult your health care provider before taking this herbal remedy. View abstract. Herbal supplements, like St. John's wort or garcinia cambogia, are much more likely to affect the functionality of your antidepressants compared to vitamins or mineral tablets. Durg S, Bavage S, Shivaram SB. Kuppurajan K, Rajagopalan SS, Sitoraman R, and et al. Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., and Deshpande, M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. low blood sugar). hydrochlorothiazide, spironolactone, chlorthalidone). View abstract. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patients specific and unique circumstances. Sometimes, these supplements are stand-alone products or multivitamins; in other cases, they are mixed in with healthy food products, like spirulina, chlorella or herbal products. 2020. Headache. Complement Ther Med 2016 Aug;27:25-9.View abstract. 2001;75(2-3):165-168. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. Read more: 8 Warning Signs of Depression You Shouldn't Ignore. 2021;45(1):176. doi:10.1186/s42269-021-00635-6, White PT, Subramanian C, Motiwala HF, Cohen MS. Natural withanolides in the treatment of chronic diseases. Information from this source is evidence-based and objective, and without commercial influence. It is also important to note that ashwagandha may interact with certain medications, such as immunosuppressants and sedatives. doi:10.7759/cureus.6466, Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. Phytother.Res 2010;24(1):129-135. Devi, P. U., Sharada, A. C., and Solomon, F. E. Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. View abstract. View abstract. A November 2013 study in the Open Neurology Journal found that vitamin B12 could also help reduce symptoms of depression, while a March 2015 study in the Australian Journal of Herbal Medicine found that several B-complex vitamins could help reduce depressive symptoms. This is because ashwagandha is thought to be an adaptogen, a substance that may help the body resist stress. People taking certain medications may need to avoid using ashwagandha. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Ashwagandha might increase the sedative effects of benzodiazepines, prescribed for conditions such as panic disorder and anxiety, and of barbiturates, primarily used for epilepsy. Compared to those who took the placebo, participants who took ashwagandha were found to have better visual memory, learning, and attention. Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. View abstract. Indian J Exp Biol. Unlike people taking SSRIs who can consume most foods without issue, people taking MAOIs need to avoid foods rich in tyramine, a nonessential amino acid. View abstract. Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. View abstract. For most people, ashwagandha is a safe and effective supplement for taking the edge off stress. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. There is concern that ashwagandha interacts with anesthesia commonly used in surgery. Monitor your blood sugar closely. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. Malhotra, C. L., Mehta, V. L., Prasad, K., and Das, P. K. Studies on Withania ashwagandha, Kaul. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. V. The effect of total alkaloids (ashwagandholine) on the central nervous system. View abstract. Copyright 2023 UpToDate, Inc. and its affiliates and/or licensors. Read our. Immunopharmacol.Immunotoxicol. 2020;10(11):e01760. These side effects may be mild or severe. One clinical trial evaluated how ashwagandha root extract affects memory and overall cognitive function. Interactions with other substances: ashwagandha may interact with certain medications, supplements, and herbs. After 30 days, those who took either dose of ashwagandha self-reported positive effects on their anxiety. Upadhaya L and et al. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Mediterranean, Low-Fat Diets Are Best for Heart Problems, Least Amount of Exercise You Need to Stay Healthy, Nerve 'Pulse' Therapy May Help Ease Sciatica, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), Antipsychotic-induced metabolic side effects, Think Your Child Has ADHD? View abstract. While the side effects of ashwagandha are minimal, some people may experience: Gastrointestinal upset. Ashwagandha may also contain withanolides, which are thought to have anti-inflammatory and antioxidant properties. Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. Moderate 623 Interactions; Unknown 2123 Interactions; Interaction Rating Key. No, Ashwagandha does not possess any qualities that cause it to be habit forming, and the risk of forming an addiction to Ashwagandha is little to none. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Neurol Sci 2000;176:124-7. Available for Android and iOS devices. Acta Pol.Pharm. Take extra care if you are using drugs to help you relax or sleep. In this randomized, double-blind, placebo-controlled trial, 125 adult participants were randomized to either 300 milligrams per day of ashwagandha sustained release or a placebo for 90 days. View abstract. Cancer Lett. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Therapeutic Research Faculty 2020. Ashwagandha has no known moderate interactions with any drugs. Ashwagandha can also interact with some medications and affect how they work. Ashwagandha can interact with diabetes, blood pressure, and immunosuppressant medications. As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. A recent study looked at the health claims and safety of ashwagandha and found that the herb has shown anticancer, anti-inflammatory, heart-protective, liver-protective, and immunomodulatory (able to change the immune system) actions. Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. Hello! Twelve studies were included in the final review, and researchers concluded that ashwagandha showed more improvements in physical performance than placebo pills. The plan to ashwagandha blood pressure medication interaction enter the company was does blood pressure medication make you put on weight quietly implemented the one from Hebei do hypertension medications affect sexuality University has already started the procedure the Yinchuan University s Zhou Qitian also agreed, and the next step is to do the school work Inner Mongolia can probiotics lower . Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. Ashwagandha might cause sleepiness and drowsiness. Phytomedicine 2000;7(6):463-469. Mixing tyramine and MAOI antidepressants can result in headache, nausea, anxiety, dangerously high blood pressure and even hemorrhagic stroke. Int Ayurvedic Med J 2013;1(5):1-7. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. However, SSRIs don't work for everyone, and other antidepressants work via different pathways in your body. View abstract. Nagashayana N, Sankarankutty P, Nampoothiri MRV, et al. View abstract. In our latest question and answer, the pharmacist discusses whether or not ashwagandha supplements interact with prescription drugs. If you have blood sugar problems, keep hard candies, glucose tablets, liquid glucose, or juice on hand for low blood sugar. Additionally, ashwagandha may increase testosterone levels in the body. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. Lousewort - Amiloride, Hydrochlorothiazide, Cassia Cinnamon - Aspirin, Butalbital, Caffeine, Abuta - Bismuth Subcarbonate, Calcium Carbonate, Opium, English Adder's Tongue - Inotuzumab Ozogamicin, Patricia Kane (pk) Protocol - Indomethacin, Pulsed Electromagnetic Field (pemf) Therapy - Cabozantinib. The effect of standardized ashwagandha extract (35% withanolide glycosides) on fatigue, vitality and associated steroid hormonal systems in healthy aging, overweight men (40 to 70 years of age; BMI, 25 to 35) was investigated via a 16-week, double-blind, randomized, placebo-controlled crossover trial (N=57). Some medications, such as those used after a transplant, decrease the activity of the immune system. Phytother Res 2022. Ahmad MK, Mahdi AA, Shukla KK, et al. View abstract. Food Chem.Toxicol. A total of 203 drugs are known to interact with levothyroxine . J Diet Suppl. Commonly prescribed SSRIs include sertraline (brand name Zoloft), paroxetine (Paxil), fluoxetine (Prozac) and citalopram (Celexa). Again, be sure to talk to your doctor about adding ashwagandha to immunosuppressant drugs. Evid Based Complement Alternat Med. View abstract. Some research shows that ashwagandha may provide benefits for stress, anxiety, memory loss, insomnia, and other health conditions. Anyone with upcoming surgery should stop using ashwagandha at least two weeks prior. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Be sure to tell your doctor if you are breastfeeding. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. Biochem.Biophys.Res Commun. It is just a general precaution that ashwagandha may decrease blood sugar. Kumar S, Bouic PJ, Rosenkranz B. Nonetheless, additional large-scale, long-term studies would strengthen these findings. Some vitamins and supplements can interfere with blood-thinning blood pressure drugs, Dr. Glatter says. 2013;12(4):312-22. J R Coll Physicians Edinb. In 2020 and 2021, some people began using ashwagandha to diminish the harmful effects of COVID-19, although there is no evidence to support that use. These medications work in the brain by indirectly enhancing the action of a chemical in the brain called gamma-aminobutyric acid (GABA) a neurotransmitter that has a calming effect which helps lower anxiety levels. It is essential to talk to your healthcare provider before taking ashwagandha if you are taking any other substances. 2021;2021:8254344. doi:10.1155/2021/8254344, Choudhary D, Bhattacharyya S, Bose S. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions. For example, ashwagandha (botanical name, Withania somnifera) is an herbal supplement found in anything from green smoothie mixes to root powder. You may think that these supplements are safe because they also have antidepressant effects, but it's not that simple. In this investigation, participants took either a placebo or 240 milligrams per day of ashwagandha extract. Ashwagandha. 1992;30(3):169-172. It's important to keep all supplements out of reach of small children and pets who may accidentally ingest more than they should. Cureus. J Clin Lab Anal 2008;22:295-301. drugs for diabetes and blood pressure). All rights reserved. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. Serotonin syndrome can even result in death. Ancient herb eases stress, boosts memory, and may help you lose weight. Bhat, J., Damle, A., Vaishnav, P. P., Albers, R., Joshi, M., and Banerjee, G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. View abstract. Another study (a systematic review and meta-analysis) found that ashwagandha may benefit athletes. More are needed for more definitive results. 9-1-2010;10(3):238-246. Dhuley, J. N. Therapeutic efficacy of Ashwagandha against experimental aspergillosis in mice. Herb-drug interactions. Another traditional use of ashwagandha in Ayurveda is for memory issues. Effect of Ashwagandha (Withania somnifera Dunal) on the process of ageing on human volunteers. Take extra care if you are at a high risk for infection. Are there any side effects of ashwagandha? For more information, read the "What else do I need to know?" section below. It is commonly used for stress. J Med Food 2022. These severity listings are for informational use only. J Ethnopharmacol. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. J Ethnopharmacol 1998;62:209-14. Ashwagandha might increase how much thyroid hormone the body produces. Some products may not mix well with other drugs or natural products. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. Immunomodulatory and CNS effects of sitoindosides 9 and 10, two new glycowithanolides from Withania somnifera. View abstract. Drug Metabol.Drug Interact. View abstract. Sleep Med. Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. View abstract. Always talk with a healthcare provider before starting any new supplement regimen. Ashwagandha has mild interactions with at least 29 different drugs. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: a randomized controlled trial. Supplements That Are Similar to Ashwagandha. Use birth control you can trust while taking this product. 2021;16(9):e0257843. Evid Based Complement Alternat Med.
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